Genesis Global Group
Integrated Analytical Solutions, Inc.

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Integrated Analytical Solutions, Inc. is a proud member of Genesis Drug Discovery & Development (GD3), a fully integrated CRO providing services to support drug discovery programs of our clients from target discovery through IND filing and managing Phase I-III clinical trials.

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IAS is your go-to source for drug metabolism testing

Specializing in GLP and non-GLP bioanalytical services using LC-MS/MS and immunoassay methods. Our team works with you to determine the right bioanalytical approach for each stage of development and every size of budget. We’re dedicated to developing methods for our client’s most challenging drug candidates and biomarkers.From off-the-shelf assays to compound-specific investigations, IAS is here to support your high-throughput screening (HTS) and lead optimization efforts for drug metabolism testing.

  • IAS has economical solutions for providing metabolic stability data for all of your early discovery screens. The data we provide will facilitate prioritization of your discovery compounds.
  • Our scientific staff is trained to provide expert guidance for metabolite identification and drug-drug interaction studies. The findings from these studies are critical to the selection of appropriate species for in vivo toxicology studies and for developing clinical testing strategies.
  • We’re always on-call to perform the analytics for your in-house metabolism experiments.

In Vitro Metabolism Assays

Our in vitro metabolism screens are an efficient approach to evaluating the stability and clearance or your test compounds in the presence of drug metabolizing enzymes.

Assay Capabilities

  • Liver, Intestinal and Renal Microsomes
  • Liver, Intestinal and Renal S9
  • Cryopreserved Hepatocytes
  • Cryopreserved Hepatocytes

Assay Features

  • Time profiles may be customized for each experiment
  • Support for investigations in all relevant species
  • Reaction conditions tailored to meet your needs for Phase I and II metabolism
In Vitro Metabolism Illustration

Metabolite Identification

As selected compounds show promise it may be necessary to further characterize the overall suitability of their bioanalytical methods. We offer various levels of bioanalytical method qualification to provide you with the assurance that a method has the desired level of accuracy, precision, sensitivity and stability for a particular stage of development. At this level, bioanalytical methods for lead candidates and critical biomarkers are further optimized and qualified to support pivotal PK studies, dose range-finding, toxicokinetic, and tissue distribution studies.IAS offers expert capabilities for identifying metabolites that may cause unintended side effects. The data acquired from these experiments is interpreted and scrutinized by our most experienced scientific staff. You can expect very detailed reports containing elucidated/proposed metabolite structures as well as sites of modification on the precursor molecule.

Metabolite ID Capabilities

  • In Vitro: analysis performed in samples from concentrated in vitro reactions
  • In Vivo: analysis performed in selected matrices from PK, Tox and Clinical studies
Metabolite Identification Illustration

Drug-Drug Interaction (DDI) Assays

Understanding compound interactions with co-dosed medications is critical to the drug development and market approval process. IAS provides DDI data to steer you toward drug candidates with reduced potential for adverse events and toxicity.

CYP450 Inhibition Studies

  • IC50 Determination
  • Single Point Inhibition Studies
Drug-Drug Interaction (DDI) Assays Illustration

Protein Binding Assays

Our protein binding assays aim to improve your understanding of the efficacy, distribution, elimination and safety profiles of your compound.

Protein Binding Capabilities

  • All Species of Plasma/Serum
  • Equilibrium Dialysis
  • Single Protein Studies Available
Protein Binding Assays Illustration

Plasma Stability Assays

Determine the extent to which your compound is a substrate for plasma enzymes.

Plasma enzymes may degrade a research compound and alter its desired effect. This can have implications for both PK screening and bioanalytical procedures. IAS offers plasma stability assays across multiple species of plasma.

Plasma Stability Assays Illustration