SERVICES
In Vitro Metabolism Assays
Our in vitro metabolism screens are an efficient approach to evaluating the stability and clearance or your test compounds in the presence of drug metabolizing enzymes.
Assay Capabilities
- Liver, Intestinal and Renal Microsomes
- Liver, Intestinal and Renal S9
- Cryopreserved Hepatocytes
- Cryopreserved Hepatocytes
Assay Features
- Time profiles may be customized for each experiment
- Support for investigations in all relevant species
- Reaction conditions tailored to meet your needs for Phase I and II metabolism
Drug-Drug Interaction (DDI) Assays
Understanding compound interactions with co-dosed medications is critical to the drug development and market approval process. IAS provides DDI data to steer you toward drug candidates with reduced potential for adverse events and toxicity.
CYP450 Inhibition Studies
- IC50 Determination
- Single Point Inhibition Studies
Protein Binding Assays
Our protein binding assays aim to improve your understanding of the efficacy, distribution, elimination and safety profiles of your compound.
Protein Binding Capabilities
- All Species of Plasma/Serum
- Equilibrium Dialysis
- Single Protein Studies Available
Plasma Stability Assays
Determine the extent to which your compound is a substrate for plasma enzymes.
Plasma enzymes may degrade a research compound and alter its desired effect. This can have implications for both PK screening and bioanalytical procedures. IAS offers plasma stability assays across multiple species of plasma.